Cardiac Troponin Assays

for Earlier Diagnosis of Myocardial Infarctions

Cardiac Troponin Assays
 
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ADVIA Centaur TnI-Ultra® Assay
The ADVIA Centaur® TnI-Ultra® assay provides clinicians with confidence to accurately rule out/in early acute myocardial infarction. The Acridinium Ester-based ADVIA Centaur TnI-Ultra assay is a highly precise assay that can measure very low concentrations of cardiac troponin I. This excellent precision exceeds the industry benchmark established by the Joint European Society of Cardiology/American College of Cardiology Committee of ≤10% CV at the 99th percentile of normal. The assay uses the patented high quantum yield AE (HQYAE) molecule which improved the analytical sensitivity by a factor of 5 over the previous ADVIA Centaur cTnI assay.

  • Supports rapid triage of chest pain patients and improves acute care workflow between serial measurements with a time to first result in 18 minutes or less.
  • Delivers confidence in the earlier detection of AMI with demonstrated clinically equivalent to high-sensitive cardiac troponin assays, meeting the guidelines criterion for ≤10%CV at the 99th percentile
  • Provides reliability in results with almost a decade in clinical practice

Assay Specifications

 ADVIA Centaur XP/CP Assay Performance Summary
Sample TypeSerum, Plasma (EDTA or Heparinized)
Sample Volume100 μL
Assay Range6 – 50,000 ng/L
Time to First Result18 minutes (XP) / 15 minutes (CP)
On-board Stability28 days
Calibration Interval28 days
Dilution2, 5, 10
Analytical Sensitivity6 ng/L
CV 10%30 ng/L
99th Percentile40 ng/L


Cardiac Menu

AssayADVIA
Centaur® Systems
IMMULITE® SystemsDimension® EXL™ Systems

Dimension®
Vista Systems

Stratus® CS Systems
BNP       √      
CKMB Mass       √        √        √        √      √
CKMB Isoenzyme          √        √ 
D-Dimer         √          √
Galectin-3       √*      
High-Sensitivity CRP          √        √        √      √
High-Sensitivity Troponin I1
       √§          √*        √*  
Myoglobin       √        √        √        √      √
NT-proBNP       √*          √        √      √
Tnl-Ultra™       √ǂ        
Troponin I          √        √ǂ        √ǂ      √ǂ

 

Assay availability may vary from country to country and subject to local regulatory requirements
*Under development. Not available for sale.
ǂGuideline-acceptable
§Not available for sale in the U.S.
1. Available on the ADVIA Centaur XP and XPT Systems only


LOCI Cardiac Troponin I Assay

The LOCI® Cardiac Troponin I assay on the Dimension® EXL™ and Dimension Vista® systems meets this standard of performance for accurate and rapid results required for timely AMI diagnosis. Employing unique oxygen channeling technology provides greater precision and low background signal with minimal noise improves sensitivity.

  • Supports rapid triage of chest pain patients and improves acute care workflow between serial measurements (6h reduced to 3h protocols) with a time to first result in 12 minutes or less.
  • Reduces the risk of interference with a low sample volume.
  • Improves laboratory workflow with same tube troponin testing with other STAT chemistry assays.
  • Delivers confidence in the earlier detection of AMI with demonstrated clinically equivalent to high-sensitive cardiac troponin assays, meeting the guidelines criterion for ≤10%CV at the 99th percentile
     

Assay Specifications

 Dimension EXL SystemsDimension Vista Systems
Sample TypeSerum, Plasma (Na or Li Heparin)Serum, Plasma (Na or Li Heparin)
Sample Volume20 μL20 μL
Assay Range17 – 40,000 ng/L15 - 40,000 ng/L
Time to First Result11 minutes12 minutes
On-board Stability

Sealed on-board (at 2-8° C): 30 days

Open well stability: 3 days

Sealed on-board (at 2-8° C): 30 days

Open well stability: 7 days